Phospho-NPM1 (Thr199) Antibody

Polyclonal Antibody

NPM1

B23 antibody, MGC104254 antibody, NO38 antibody, NPM antibody, NPM_HUMAN antibody, NPM1 antibody, Nucleolar phosphoprotein B23 antibody, Nucleolar protein NO38 antibody, Nucleophosmin (nucleolar phosphoprotein B23 numatrin) antibody, Nucleophosmin antibody, nucleophosmin nucleoplasmin family member 1 antibody, Nucleophosmin/nucleoplasmin family member 1 antibody, Numatrin antibody, OTTHUMP00000161024 antibody, OTTHUMP00000161025 antibody, OTTHUMP00000223397 antibody, OTTHUMP00000223398 antibody

Peptide sequence around phosphorylation site of Threonine 199(R-D-T(p)-P-A) derived from Human NPM.

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Epigenetics and Nuclear Signaling

Peptide sequence around phosphorylation site of Threonine 199(R-D-T(p)-P-A) derived from Human NPM.