FEN1

ArtNr	18-272-198048
Hersteller	GENWAY
Menge	0.1 ml
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-670BF0
Similar products	18-272-198048
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Genway ID:	GWB-670BF0
Isotype:	IgG
Immunogen:	Recombinant full-length human FEN-1 protein
Antigen Species:	Human
Positive Control:	HeLa Raji 3T3
Target:	FEN1
Localization:	Nuclear
Concentration:	Antiserum
Purification Note:	Antiserum Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	For WB: Use at a dilution of 1:2 500. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein
Molecular Weight:	42 Cellular
Localization:	Nuclear FEN-1 (Flap EndoNuclease and Five prime Exonuclease) is a 42 kDa protein that functions as an endonuclease when it cleaves branched DNA structures containing single-stranded 5\' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.
Function:	Endonuclease that cleaves the 5\' -overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5\' -end of a downstream Okazaki fragment. Also possesses 5\' to 3\' exonuclease activity on niked or gapped double-stranded DNA and exhibits RNase H activity.
Subunit:	Interacts with PCNA. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300.
Subcellular Location:	Nucleus.
Ptm:	Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
Similarity:	Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

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