anti-Transglutaminase 2 (2A1)

Hersteller Hoelzel
Kategorie Produkte
Typ Antibody Monoclonal
Specific against Human
Clon 2A1
Applikationen E, WB
Menge 100 ul
ArtNr HZ-MA0093
Lieferbar
Description
Mouse monoclonal to Human Serum Albumin
Immunogen
Purified human serum albumin protein
Applications
E WB (1:2, 000) IP (1 ul)
Background
Human serum albumin (HSA) is the most abundant protein in mammalian plasma and is generally considered to be a multifunctional transport protein. HSA is a signle-chain protein synthesized in and secreted from liver cells. HSA has significant antioxidant activity and may represent the major and predominant circulating antioxidant in plasma, which is known to be exposed to continuous oxidative stress. HSA protects human low density lipoproteins against copper-mediated oxidation and blood against hemolysis by free radicals. HSA which are exposed to glucose and have a relatively slow turnover rate are particularly susceptible to nonenzymatic glycosylation. Structural changes in glycosylated albumin lead to a reduction in affinity for fatty acid.
Reference
1) Keisuke Nakajou et al. (2003) Biochimica et Biophysica Acta 1623:88-97. 2) Makoto Anraku et al. (2001) Pharmaceutical Research 18(5):632-639. 3) Nurith Shaklai et al. (1984) The Journal of Biological Chemistry 259(6):3812-3817.
Research Area
Serum Protein, Disease Marker
SwissProt
P02768
GeneId
213
Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Subcellular Location
Secreted
Positive Control
Human plasma
Composition
HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
storage
Store for 1 year at -20C from date of shipment. Aliquot to avoid repeated freezing and thawing.
Purification
Ammonium sulfate precipitation
Conjugation
unconjugated
Menge: 100 ul
Lieferbar: In stock
Listenpreis: 238,00 €
Preis: 238,00 €
lieferbar

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Arbeitsanleitung

HZ-MA0093.pdf