Beclabuvir

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-12429-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
BMS-791325, BMS791325, BMS 791325
CAS No.
958002-33-0
Purity
>98%
MW
659838
Formula
C36H45N5O5S
Solubility
DMSO: >= 30 mg/mL
Biological Description
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM.
IC50 & Target: IC50: < 28 nM (NS5B protein)
In Vitro: Beclabuvir demonstrates additive or synergistic antiviral activity with pegIFN/RBV and in 2- or 3-drug combinations with a range of DAAs, such as HCV NS3 protease inhibitors, NS5A inhibitors' and/or nucleoside NS5B inhibitors[2].
In Vivo: The combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide[1].

Sicherheitsdatenblatt

HY-12429-5mg.pdf

Menge: 5mg
Lieferbar: In stock
Listenpreis: 460,36 €
Rabatt: -10,0%
Preis: 414,32 €
Sie sparen: 46,04 €
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