G007-LK

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-12438-5mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
G007 LK, G007LK
CAS No.
1380672-07-0
Purity
>98%
MW
5299576
Formula
C25H16ClN7O3S
Solubility
DMSO: >= 30 mg/mL
Biological Description
G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice.
IC50 value: 46 nM/23 nM (TNKS1/TNKS2) [1]
Target: Tankyrase inhibitor
G007-LK shows a favorable combination of high target specificity to TNKS1/2, high potency, and in vitro as well as in vivo stability, leading to a good pharmacokinetic profile in mice. G007-LK shows a greater selectivity toward TNKS proteins. G007-LK extends the possibilities to selectively inhibit TNKS1/2 in vitro and in vivo. G007-LK provides an excellent small molecule for analyzing the functions of TNKS1/2 and Wnt/beta-catenin signaling in cell biology,
cancer, and disease models.
Menge: 5mg
Lieferbar: In stock
Listenpreis: 166,79 €
Rabatt: -10,0%
Preis: 150,11 €
Sie sparen: 16,68 €
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