DM4

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12454-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Description
DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. In Vitro: DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].
CAS No.
796073-69-3
Purity
>98%
MW
780, 3674
Formula
C38H54ClN3O10S
Solubility
DMSO: 10 mM
Clinical Phase
Phase 2
Signalling Pathway
Cell Cycle/DNA Damage; Cytoskeleton
Target
Microtubule/Tubulin; Microtubule/Tubulin

Sicherheitsdatenblatt

HY-12454-10mM.pdf

Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 552,50 €
Rabatt: -10,0%
Preis: 497,25 €
Sie sparen: 55,25 €
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