OTS-964

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-12467-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS No.
1338545-07-5
Purity
>98%
MW
4289748
Formula
C23H25ClN2O2S
Solubility
10 mM in DMSO
Biological Description
OTS964 is a potent TOPK inhibitor with an IC50 value of 28 nM.
IC50 value: 28 nM
Target: TOPK
in vitro: OTS964 is a dimethylated derivative of OTS514. OTS964 can inhibit TOPK kinase activity with high affinity and selectivity. TOPK (T-lymphokine-activated killer cell-originated protein kinase) is a protein that is found in a wide range of human cancers and is believed to work as an oncogene, promoting tumor growth. OTS964 inhibits the growth of TOPK-positive cells with low IC50 values [A549 (31 nM), LU-99 (7.6 nM), DU4475 (53 nM), MDA-MB-231 (73 nM), T47D (72 nM), Daudi (25 nM), UM-UC-3 (32 nM), HCT-116(33nM), MKN1(38nM), MKN45(39nM), HepG2(19nM), MIAPaca-2 (30 nM), and 22Rv1 (50 nM)]. [1]
in vivo: OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), OTS964 causes a cytokinesis defect and the subsequent apoptosis of cancer cells in xenograft models of human lung cancer.
Menge: 5mg
Lieferbar: In stock
Listenpreis: 245,00 €
Preis: 245,00 €
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