Decernotinib

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 50mg
ArtNr HY-12469-50mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
VX-509, VRT-831509
CAS No.
944842-54-0
Purity
>98%
MW
3923783
Formula
C18H19F3N6O
Solubility
10 mM in DMSO
Biological Description
Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.
IC50 value: 2.5 nM(Ki) [1]
Target: JAK3
in vitro: VX-509 potently inhibits JAK3 in enzyme assays (Ki =2.5 nM + 0.7 nM) and cellular assays dependent on JAK3 activity (IC50 range, 50-170 nM), with limited or no measurable potency against other JAK isotypes or non-JAK kinases [1].
in vivo: VX-509 also showed activity in two animal models of aberrant immune function. VX-509 treatment resulted in dose-dependent reduction in ankle swelling and paw weight and improved paw histopathology scores in the rat collagen-induced arthritis (CIA) model. In a mouse model of oxazolone-induced delayed-type hypersensitivity (DTH), VX-509 reduced the T-cell-mediated inflammatory response in skin [1].
Menge: 50mg
Lieferbar: In stock
Listenpreis: 636,07 €
Preis: 636,07 €
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