BMH-21

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 100mg
ArtNr HY-12484-100mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Description
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX. IC50 value: 10-90 nM(RPA195 IC50) [1] Target: RNA Pol I inhibitor in vitro: BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress [1].
CAS No.
896705-16-1
Purity
>98%
MW
360, 4091
Formula
C21H20N4O2
Solubility
10 mM in DMSO
Clinical Phase
No Development Reported
Signalling Pathway
Cell Cycle/DNA Damage
Target
DNA/RNA Synthesis
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 100mg
Lieferbar: In stock
Listenpreis: 494,64 €
Preis: 494,64 €
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