Paritaprevir

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 100mg
ArtNr HY-12594-100mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
ABT-450, Veruprevir
CAS No.
1216941-48-8
Purity
>98%
MW
7658771
Formula
C40H43N7O7S
Solubility
10 mM in DMSO
Biological Description
Paritaprevir is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively.
IC50 & Target: EC50: 1 nM(HCV 1a), 0.21 nM(HCV 1b)[1]
In Vitro: Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].
In Vivo: The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1[1].
Publications
Antiviral Res. 2017 Mar; 139:18-24.
Chem Cent J. 2017 Jan 3; 11:1.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 100mg
Lieferbar: In stock
Listenpreis: 1.151,43 €
Preis: 1.151,43 €
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