SP2509

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12635-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
SP-2509
CAS No.
1423715-09-6
Purity
>98%
MW
4378972
Formula
C19H20ClN3O5S
Solubility
DMSO: >= 33 mg/mL
Biological Description
SP2509 is a potent and selective antagonist of lysine specific demethylase 1 (LSD1) with IC50 of 13 nM.
IC50 & Target: IC50: 13 nM (LSD1)[1]
In Vitro: SP2509 (250, 500, 1000 nM) inhibits LSD1 activity, depletes colony growth and induces apoptosis and cell death of cultured human acute myeloid leukemia cells, and increases H3K4Me3 on the promoters of p57 Kip, KLF4, and p21 and induces mRNA expression of p57Kip, KLF4 and p21 in AML cells. SP2509 (250, 1000 nM) induces features of morphologic differentiation of cultured and primary AML cells. Besides, SP2509 in combination with PS exerts synergistic lethal activity against cultured and primary AML cells[1]. SP2509 does not destabilize the CoREST-LSD1 interaction, and has no major destabilizing effect on the CRC. SP2509 (1 or 10 uM) induces cell death, but there are no morphological changes at a low concertation of 0.1 uM. SP2509 likewise interferes with the viability of medulloblastoma cells[2].
In Vivo: Treatment with SP2509 (25 mg/kg) and/or PS (5 mg/kg) significantly enhances PS-mediated loss of viability of CD34+ primary AML cells and improves the survival of mice bearing AML xenografts and primagrafts[2].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 172,14 €
Preis: 172,14 €
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