Acalisib

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-12644-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
GS-9820, GS9820, GS 9820, CAL-120, CAL120, CAL 120
CAS No.
870281-34-8
Purity
>98%
MW
4013965
Formula
C21H16FN7O
Solubility
DMSO: >= 29 mg/mL
Biological Description
Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kdelta with IC50 value of 12.7 nM.
IC50 value: 12.7 nM [1]
Target: PI3Kdelta
in vitro: GS-9820 is more selective for PI3Kdelta relative to other PI3K class I enzymes (IC50: PI3Kalpha, 5, 441 nM; PI3Kbeta, 3, 377 nM; PI3Kgamma, 1, 389 nM; and PI3Kdelta, 12.7 nM) . GS-9820 suppresses Fc RI PI3Kdelta-mediated CD63 expression with an EC50 of 14 nM, and fMLP PI3Kgamma-mediated CD63 expression with an EC50 of 2, 065 nM. GS-9820 shows selectivity for PI3Kdelta over the other class I PI3K isoforms and virtually no binding to a panel of other kinases. [1]
Menge: 10mg
Lieferbar: In stock
Listenpreis: 225,71 €
Rabatt: -10,0%
Preis: 203,14 €
Sie sparen: 22,57 €
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