PE859

Hersteller MedChem Express
Kategorie Produkte / Inhibitors
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-12662-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
PE-859, PE 859
CAS No.
1402727-29-0
Purity
>98%
MW
4485157
Formula
C28H24N4O2
Solubility
DMSO: >= 30 mg/mL
Biological Description
PE859 is a potent inhibitor of both tau and Abeta aggregation with IC50 values of 0.66 and 1.2 uM, respectively.
IC50 & Target: IC50: 0.66 uM (tau), 1.2 uM (Abeta)[1]
In Vitro: PE859 inhibits the heparin-induced aggregation of both 3RMBD and full length tau in a concentration-dependent manner. In each assay, the IC50 values calculated at the last measurement periods are 0.81 uM, and 2.23 uM, respectively. PE859 inhibits tau aggregation through formation of beta-sheet structure[2].
In Vivo: PE859 could cross the blood-brain barrier and that PE859 could be distributed into the tissues of the central nervous system. The maximum concentration of PE859 is 2.005 ug/mL in the blood at 3 h and 1.428 ug/g in the brain at 6 h. PE859 delays onset and progression of the motor dysfunction in JNPL3 mice. PE859 delays progression of the motor dysfunction through the inhibition of accumulation of sarkosyl-insoluble tau. [2]

Menge: 10mg
Lieferbar: In stock
Listenpreis: 636,07 €
Preis: 636,07 €
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