QS11

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12762-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS No.
944328-88-5
Purity
>98%
MW
567, 6795
Formula
C36H33N5O2
Solubility
DMSO: 10 mM
Clinical Phase
No Development Reported
Signalling Pathway
Others
Target
Others
Biological Description
QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. In Vitro: QS11 binds and inhibits the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), suggesting that QS11 modulates Wnt/beta-catenin signaling through an effect on protein trafficking. QS11 (2.5 uM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a CM, whereas Wnt-3a treatment alone increases reporter activity 40-fold. QS11 increases reporter activity only 2-fold in the absence of Wnt-3a. QS11 shows potent activity (EC50=0.5 uM) with little cytotoxicity toward HEK293 and human primary fibroblast cells. QS11 effectively reduces in vitro migration of metastatic human breast cancer cells[1].
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 181,79 €
Rabatt: -10,0%
Preis: 163,61 €
Sie sparen: 18,18 €
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