CNV1014802 (hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-12796A-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
GSK-1014802 hydrochloride, CNV-1014802 hydrochloride, Raxatrigine hydrochloride
CAS No.
934240-31-0
Purity
>98%
MW
350815
Formula
C18H20ClFN2O2
Solubility
DMSO: >= 31 mg/mL
Biological Description
CNV1014802(GSK-1014802) Hcl is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.
IC50 value:
Target: sodium channel blocker
Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. CNV1014802 received orphan-drug designation from the US Food and Drug Administration in July 2013.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5mg
Lieferbar: In stock
Listenpreis: 225,71 €
Preis: 225,71 €
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