6-Alpha Naloxol

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-12799-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Alpha-Naloxol
CAS No.
20410-95-1
Purity
>98%
MW
3293902
Formula
C19H23NO4
Solubility
10 mM in DMSO
Biological Description
6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist closely related to naloxone; a human metabolite of naloxone.
IC50 value:
Target: opioid antagonist
When responding over the entire 30 min operant session was examined, naloxone was only 5-fold more potent than 6-alpha-naloxol in suppressing operant responding under Morphine Na ve conditions, but this increased to a 65-fold potency difference after Single or Repeat Morphine pretreatment. Examination of the relative potency of these antagonists in the Early Phase of operant testing (5-15 min post-antagonist) revealed an even greater 100-fold potency difference between naloxone and 6-alpha-naloxol, but in the Late Phase of testing (25-35 min post-antagonist), this had declined to a 9-fold potency difference, comparable to the relative potency of naloxone to 6-alpha-naloxol under Morphine-Na ve conditions.
Menge: 5mg
Lieferbar: In stock
Listenpreis: 577,14 €
Preis: 577,14 €
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