UM171

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 25mg
ArtNr HY-12878-25mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS
1448724-09-1
Biological activity
UM171 is a selective agonist of human hematopoietic stem cell self-renewal.
In Vitro: UM171 (50-100 nM) significantly increases CD34+ CD43+ and CD34+ CD45+ hematopoietic progenitors. UM171 enhances the derivation of hematopoietic cells at multiple developmental steps. UM171 enhances de novo generation of hematopoietic progenitor cells from hPSCs at multiple phases during hematopoietic differentiation in vitro. UM171 shows no effect on erythroid development, but inhibits erythroid maturation[1]. UM171 treatment enhances the engraftment potential of CD34+ macaque cells by threefold. UM171 attenuates cell differentiation and promotes ex vivo expansion of primitive human hematopoietic cells, and promotes expansion of LT-HSCs. UM171 treatment results in down-regulation of AhR target genes such as CYP1B1, CYP1A1, and AhRR[2].
MW
453.5422
Formula
C25H27N9
Smiles
N[CH]1CC[CH](NC2=C3C(NC4=C3C=CC(C5=NN(C)N=N5)=C4)=NC(CC6=CC=CC=C6)=N2)CC1
Solubility
DMSO: >= 75 mg/mL
Clinical phase
No Development Reported
Pathway
Others
Target
Others
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 25mg
Lieferbar: Out of stock
Listenpreis: 406,79 €
Preis: 406,79 €
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