EPZ020411 hydrochloride

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 2mg
ArtNr HY-12970A-2mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
EPZ-020411 hydrochloride, EPZ 020411 hydrochloride
Purity
>98%
MW
479, 0551
Formula
C25H39ClN4O3
Solubility
H2O: >= 41 mg/mL
Clinical Phase
No Development Reported
Signalling Pathway
Epigenetics
Target
Histone Methyltransferase
Biological Description
EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ?10 fold selectivity for PRMT6 over PRMT1 and PRMT8. IC50 value: 10 nM Target: PRMT6 in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells. in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!

Sicherheitsdatenblatt

HY-12970A-2mg.pdf

Menge: 2mg
Lieferbar: In stock
Listenpreis: 166,79 €
Rabatt: -10,0%
Preis: 150,11 €
Sie sparen: 16,68 €
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