Fagomine

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-13005-10mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
D-Fagomine
CAS No.
53185-12-9
Purity
>98%
MW
1471723
Formula
C6H13NO3
Solubility
H2O: >= 36 mg/mL
Biological Description
Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 uM, 39 uM, and 70 uM for Amyloglucosidase (A.niger), beta-Glucosidase (bovine), and Isomaltase (yeast), respectively.
IC50 & Target: Glycosidase[1]
In Vitro: Fagomine (D-fagomine) is an iminosugar that has been shown to selectively agglutinate Enterobacteriales in vitro. Fagomine selectively agglutinates fimbriated enterobacteria (e.g., E.coli) and inhibits their adhesion to the intestinal mucosa; the reason for this is probably related to its structural similarity with lectin-binding saccharides (e.g., mannose). Fagomine is capable of altering this effect of high-fat high-sucrose diet (HFHS) on the proportion of Enterobacteriales and E.coli[2].
In Vivo: Fagomine (D-fagomine) is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales[3]. Compare to the standard group, rats fed high-fat high-sucrose diet (HFHS) with Fagomine (D-fagomine) gain significantly less weight (15.3%) than those fed HFHS (20.9%)[2].
Publications
J Pharm Biomed Anal. 2015 Feb 19; 109:177-183.
J Pharm Biomed Anal. 2015 Jun 20; 114:447-454.
Menge: 10mg
Lieferbar: In stock
Listenpreis: 928,57 €
Rabatt: -10,0%
Preis: 835,71 €
Sie sparen: 92,86 €
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