NSC59984

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 100mg
ArtNr HY-19726-100mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
NSC 59984, NSC-59984
CAS No.
803647-40-7
Purity
>98%
MW
2652652
Formula
C12H15N3O4
Solubility
DMSO: >= 38 mg/mL
Biological Description
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
IC50 value: 8.38 uM (EC50, for p53-null HCT116 cells)
Target: p53
in vitro: NSC59984 specifically restores p53 pathway signaling in mutant p53-expressing human colorectal cancer cells. NSC59984 induces cell death in tumor cells but not normal cells with little or no genotoxicity. NSC59984 induces mutant p53 protein degradation through MDM2-mediated ubiquitination in cancer cells. NSC59984 restores p53 pathway signaling through activation of p73. NSC59984 induces p73-dependent cell apoptosis in cancer.
in vivo: NSC59984 synergizes with CPT11 to induce cell death in mutant p53-expressing colorectal cancer cells and inhibits mutant p53-associated colon tumor xenograft growth in a p73-dependent manner.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 100mg
Lieferbar: In stock
Listenpreis: 1.689,29 €
Rabatt: -10,0%
Preis: 1.520,36 €
Sie sparen: 168,93 €
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