Dabigatran (ethyl ester hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 100mg
ArtNr HY-77521-100mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS No.
211914-50-0
Purity
>98%
MW
5360252
Formula
C27H30ClN7O3
Solubility
DMSO: 10 mM
Biological Description
Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 uM and a thrombin inhibitor.
IC50 & Target: IC50: 0.8 uM (NQO2)[1]
In Vitro: The Ki of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 uM and the IC50 is 0.8 uM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2[1]. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate[2].
In Vivo: Dabigatran (Ki=4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect[3].
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Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 100mg
Lieferbar: In stock
Listenpreis: 869,64 €
Preis: 869,64 €
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