Nelociguat

Hersteller MedChem Express
Kategorie Produkte / Inhibitors
Typ Inhibitors
Specific against other
Menge 1g
ArtNr HY-78237-1g
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
BAY60-4552
CAS No.
625115-52-8
Purity
>98%
MW
4083891
Formula
C19H17FN8O2
Solubility
DMSO: >= 105 mg/mL (Need ultrasonic)
Biological Description
Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.
In Vitro: Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway[1]. Riociguat is metabolized to BAY60-4552 not only via cytochrome P450 isoenzymes 3A4 (CYP3A4), CYP2C8, and CYP2J2, but also via CYP1A1, located in the liver and lungs[2].
In Vivo: GSK2181236A and BAY 60-4552 provide partial benefit against hypertension-induced end-organ damage. In spontaneously hypertensive stroke-prone rats, a low dose of BAY 60-4552 decreases urine output and improved survival. A high dose also reduces urine output, and in addition reduces microalbuminuria and attenuates the increase in mean arterial pressure. Both the 0.3 and 3 mg/kg/day doses of BAY 60-4552 improves survival of 46 and 69%. Seven weeks of treatment with BAY 60-4552 (0.3 and 3.0 mg/kg/day) dose-dependently decreases urine output to 79+/-11 and 56+/-10 mL/day[1]. BAY 60-4552, and vardenafil provides synergistic beneficial effects and might therefore salvage patients who experience treatment failures with PDE5 inhibitors after radical prostatectomy[3].
Menge: 1g
Lieferbar: In stock
Listenpreis: 1.185,71 €
Preis: 1.185,71 €
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