AZD-9291 (dimesylate)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 5mg
ArtNr HY-79077-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Osimertinib dimesylate, Mereletinib dimesylate, AZD 9291 dimesylate
Purity
>98%
MW
6918187
Formula
C30H41N7O8S2
Solubility
DMSO: ? 10 mM
Biological Description
AZD-9291 dimesylate is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).
IC50 value: 12.92 nM(Exon 19 deletion EGFR); 11.44 nM(L858R/T790M EGFR) [1]
Target: L858R/T790M EGFR; Exon 19 deletion EGFR
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines.
Patent: WO 2013014448
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5mg
Lieferbar: In stock
Listenpreis: 108,93 €
Preis: 108,93 €
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