MMAF-OMe

Hersteller MedChem Express
Kategorie Produkte / Inhibitors
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-79256-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Monomethyl auristatin F methyl ester
CAS No.
863971-12-4
Purity
>98%
MW
7459887
Formula
C40H67N5O8
Solubility
DMSO
Biological Description
MMAF-OMe inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
IC50:
Target:tubulin
In vitro:
In vivo: 2.5F-Fc and 2.5F-Fc-MMAF have similar IC50 values (6.9 +/- 1.1 vs. 8.3 +/- 1.3 nmol/L, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity[1].
Menge: 10mg
Lieferbar: In stock
Listenpreis: 693,93 €
Preis: 693,93 €
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