MRE-269

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 50mg
ArtNr HY-79593-50mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
ACT-333679, MRE269, MRE 269, ACT333679, ACT 333679
CAS No.
475085-57-5
Purity
>98%
MW
4195161
Formula
C25H29N3O3
Solubility
DMSO: >= 51 mg/mL
Biological Description
MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
In Vitro: MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC[1]. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-)[3].
In Vivo: The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA[1]. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 uM (pEC50, 4.98+/-0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 uM[2].
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Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 50mg
Lieferbar: In stock
Listenpreis: 1.338,93 €
Preis: 1.338,93 €
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