SJB3-019A

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-80012-10mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Purity
>98%
MW
2762463
Formula
C16H8N2O3
Solubility
10 mM in DMSO
Biological Description
SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 uM.

IC50 & Target: IC50: 78.1 nM (ID1)
In Vitro: SJB3-019A (IC50=0.0781 uM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity[1].
Publications
Blood. 2015; 126(23):1813.
Blood. 2016 128:3290.
Journal
Deepika Sharma Das, et al. Deubiquitylating Enzyme USP1 As Therapeutic Target in Multiple Myeloma. Blood. 2016 128:3290.
Menge: 10mg
Lieferbar: In stock
Listenpreis: 472,14 €
Rabatt: -10,0%
Preis: 424,93 €
Sie sparen: 47,21 €
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