Formoterol

3444048

Formoterol(Arformoterol) is a novel highly beta2-selective adrenergic agonist and holds promise as a beta2-agonist that could impart selective beneficial metabolic effects.
IC50 Value:
Target: beta2-selective adrenergic agonist
in vitro: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1[1]. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kdelta-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM [3].
in vivo: Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor gamma coactivator 1alpha, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1beta subcomplex subunit 8) [2]. Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively [4].