Docetaxel (Trihydrate)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 100mg
ArtNr HY-B0011A-100mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS No.
148408-66-6
Purity
>98%
MW
861925
Formula
C43H59NO17
Solubility
10 mM in DMSO
Biological Description
Docetaxel Trihydrate is a semi-synthetic taxane analogue, acts as a microtubule stabilizer.
IC50 & Target: Microtubule[1]
In Vitro: Docetaxel (DOC) and Glufosfamide (GLU) single and combined treatments affect the cells viability in a dose-dependent manner. The IC50 of GLU are 70+/-4 uM and 86.8+/-8 uM in PC-3 and LNCaP cells; respectively. While, the IC50 of Docetaxel alone is found to be 3.08+/-0.4 nM and 1.46+/-0.2 nM in PC-3 and LNCaP cells; respectively. The co-treatment of GLU with Docetaxel is found to synergize the cytotoxicity and the IC50 values are decreased to be 2.7+/-0.1 nM and 0.75+/-0.3 nM in PC-3 and LNCaP cells; respectively[1]. IC50 of NCI-H460 to Docetaxel at 24 h is 116 nM and at 72 h is 30 nM. According to data reported in DTP Data Search, the mean IC50 of NCI-60 cell panel to Docetaxel is 14-34 nM[2].
In Vivo: In female mice, the Docetaxel-induced intestinal apoptosis in the 14-hours after light on (HALO) group is significantly greater than that in the 2-HALO group. Bax expression is significantly elevated by Docetaxel in the 2-HALO group, but not in the 14-HALO group. On the other hand, cleaved Caspase-3 expression is significantly elevated by Docetaxel in the 14-HALO group, but not in the 2-HALO group. The expressions of Wee1 and phosphorylated CKD1 are significantly elevated after dosing of Docetaxel at 14 HALO, but not at 2 HALO. In addition, Docetaxel significantly reduces survivin expression in the 14-HALO group but not in the 2-HALO group. The survivin expression level in the Docetaxel-treated 14-HALO group is significantly smaller than that in the drug-treated 2-HALO group[3]. Piperine (PIP) is administrated via intravenous bolus at 3.5 mg/kg and via oral administration at 35 mg/kg and 3.5 mg/kg, while Docetaxel (DOX) is intravenously administrated at 7 mg/kg to Sprague-Daley rats. The co-administrations of PIP at 35 mg/kg via oral administration and Docetaxel at 7 mg/kg via intravenous bolus administration in Sprague-Dawley rats. The combination use of PIP and Docetaxel results in a synergic increase of both their in vivo exposure[4].
Menge: 100mg
Lieferbar: In stock
Listenpreis: 120,71 €
Rabatt: -10,0%
Preis: 108,64 €
Sie sparen: 12,07 €
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