Tropisetron (Hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 100mg
ArtNr HY-B0020-100mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
SDZ-ICS 930
CAS No.
105826-92-4
Purity
>98%
MW
3208138
Formula
C17H21ClN2O2
Solubility
10 mM in DMSO
Biological Description
Tropisetron is a selective 5-HT3 receptor antagonist and alpha7-nicotinic receptor agonist with an IC50 of 70.1 +/- 0.9 nM for 5-HT3 receptor.
IC50 value: 70.1 +/- 0.9 nM
Target: 5-HT3 receptor; alpha7-nicotinic receptor
in vitro: Retinal ganglion cells(RGCs) pretreated with 100 nM tropisetron before glutamate increased cell survival to an average of 105% compared to controls. Inhibition studies using the alpha7 nAChR antagonist, MLA (10 nM), support the hypothesis that tropisetron is an effective neuroprotective agent against glutamate-induced excitotoxicity; mediated by alpha7 nAChR activation. Tropisetron had no discernible effects on pAkt levels but significantly decreased p38 MAPK levels associated with excitotoxicity from an average of 15 ng/ml to 6 ng/ml [2]. Tropisetron, but not granisetron, significantly inhibits the phosphatase activity of calcineurin, over-expresses the CB(1) receptors at both transcriptional and protein levels, and reduces cAMP content in cerebellar granule neurons (CGNs) [4].
in vivo: Animals were treated intracerebroventricularly with tropisetron, mCPBG (selective 5-HT3 receptor agonist) or mCPBG plus tropisetron on days 1, 3, 5 and 7. Tropisetron significantly diminished the elevated levels of these markers and reversed the cognitive deficit. Interestingly, tropisetron was also found to be a potent inhibitor of calcineurin phosphatase activity [1]. tropisetron (5mg/kg/day) plus mCPBG (10mg/kg/day), and granisetron (5mg/kg/day) intraperitoneally on days 3-35 post-immunization. Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p<0.001) and reduced leukocyte infiltration as well as demyelination in the spinal cord (p<0.05) [3].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 100mg
Lieferbar: In stock
Listenpreis: 166,79 €
Rabatt: -10,0%
Preis: 150,11 €
Sie sparen: 16,68 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen