Amrubicin

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 1mg
ArtNr HY-B0067-1mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
AMR
CAS No.
110267-81-7
Purity
>98%
MW
4834673
Formula
C25H25NO9
Solubility
DMSO: >= 30 mg/mL
Biological Description
Amrubicin(SM-5887) is a novel anthracycline derivative for treatment of bladder carcinoma.
Target: Others
Amrubicin (SM-5887) is an anthracycline used in the treatment of lung cancer. The distribution of SM-5887 in the bladder mucosa and muscular layer was almost equal, but the concentration of its active metabolite, 13-OH derivative, was 5 to 10 times higher in the bladder mucosa than in the bladder muscular layer. The distributions of SM-5887 in the organs other than the bladder, that is, the cortex and medulla of kidney, heart, lung, liver, and spleen, were very low, and those of a 13-OH active metabolite were even lower. In addition, SM-5887 barely affected the normal bladder mucosa. In dogs instilled with 80 mg of SM-5887, no histological change was observed in the bladder mucosa and submucosal layer even after 6-hour retention at the highest concentration of 8, 000 micrograms/ml [1]. phase II clinical trial of SM-5887, a new totally synthesized anthracycline derivative, was carried out in 13 patients with inoperable or recurrent gastric cancer. No patient had been given anthracycline previously. SM-5887 was administered by I.V. bolus with a dose of 100 mg/m2 every three weeks. Twelve of 13 cases were eligible and evaluable for the response. Of the 12 evaluated cases, 6 showed no change (NC), including one minor response (MR) [2].
Menge: 1mg
Lieferbar: In stock
Listenpreis: 225,71 €
Rabatt: -10,0%
Preis: 203,14 €
Sie sparen: 22,57 €
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