Amrubicin (hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-B0067A-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
AMR hydrochloride
CAS No.
110311-30-3
Purity
>98%
MW
5199282
Formula
C25H26ClNO9
Solubility
10 mM in DMSO
Biological Description
Amrubicin hydrochloride (SM-5887 hydrochloride) is a topoisomerase II inhibitor used in the treatment of lung cancer.
Target: Topoisomerase II
SM-5887 is a novel anthracycline derivative. The distribution of SM-5887 in the bladder mucosa and muscular layer was almost equal, but the concentration of its active metabolite, 13-OH derivative, was 5 to 10 times higher in the bladder mucosa than in the bladder muscular layer. The distributions of SM-5887 in the organs other than the bladder, that is, the cortex and medulla of kidney, heart, lung, liver, and spleen, were very low, and those of a 13-OH active metabolite were even lower. In addition, SM-5887 barely affected the normal bladder mucosa. In dogs instilled with 80 mg of SM-5887, no histological change was observed in the bladder mucosa and submucosal layer even after 6-hour retention at the highest concentration of 8, 000 micrograms/ml [1]. SM-5887 is possibly most potent for the treatment of NSCLC, and that these drugs have less cardiotoxicity compared to the mother compound, doxorubicin [2].
Menge: 5mg
Lieferbar: In stock
Listenpreis: 577,14 €
Preis: 577,14 €
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