Ivabradine (hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 10mg
ArtNr HY-B0162A-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS No.
148849-67-6
Purity
>98%
MW
5050461
Formula
C27H37ClN2O5
Solubility
DMSO: >= 51 mg/mL
Biological Description
Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 uM, which is a pure heart rate lowering agent.
IC50 Value: 2.9 uM
Ivabradine acts on the If (f is for "funny", so called because it had unusual properties compared with other current systems known at the time of its discovery) ion current, which is highly expressed in the sinoatrial node. If is a mixed Na+–K+ inward current activated by hyperpolarization and modulated by the autonomic nervous system. It is one of the most important ionic currents for regulating pacemaker activity in the sinoatrial (SA) node. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner. Blocking this channel reduces cardiac pacemaker activity, slowing the heart rate and allowing more time for blood to flow to the myocardium.From wikipedia.



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Sicherheitsdatenblatt

HY-B0162A-10mg.pdf

Menge: 10mg
Lieferbar: In stock
Listenpreis: 99,29 €
Rabatt: -10,0%
Preis: 89,36 €
Sie sparen: 9,93 €
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