L-(-)-alpha-Methyldopa (hydrate)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 10mM*1mL (in DMSO)
ArtNr HY-B0225B-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
MK-351 hydrate, Methyldopa hydrate
CAS No.
41372-08-1
Purity
>98%
MW
238.24
Formula
C10H13NO4 . 3/2 H2O
Solubility
10 mM in DMSO
Biological Description
L-(-)-alpha-Methyldopa hydrate is an alpha-adrenergic agonist (selective for alpha2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.
Target: alpha-adrenergic agonist
Methyldopa is an alpha-adrenergic agonist (selective for alpha2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)).
Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. This effect may lower blood pressure and cause central nervous system effects such as depression, anxiety, apathy, anhedonia, and parkinsonism. It is converted to alpha-methylnorepinephrine by dopamine beta-hydroxylase (DBH). alpha-methylnorepinephrine is an agonist of presynaptic central nervous system alpha2-adrenergic receptors. Activation of these receptors in the brainstem appears to inhibit sympathetic nervous system output and lower blood pressure. This is also the mechanism of action of clonidine.
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Menge: 10mM*1mL (in DMSO)
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