Antibodies

SHP Antibody [SH2G5-C]

Hersteller ProSci
Kategorie
Typ Antibody Primary
Specific against Human
Clon SH2G5-C
Isotype IgG2a kappa
Format Liquid
Applikationen WB, ELISA
Menge 100 ug
Host Rat
ArtNr 36-015
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Background
Small heterodimer partner (SHP) is a 257-amino acid orphan nuclear receptor expressed in the liver, pancreas, spleen, small intestine, and adrenal gland in humans. SHP inhibits the transcriptional activity of hepatocyte nuclear factor-4alpha (HNF4alpha). Recently a cohort of Japanese patients with maturity onset diabetes of the young (MODY) were screened and seven mutations found that result in impaired inhibition of HNF-4[alpha] transcriptional activity in vitro. Defects in NR0B2 may be associated with early-onset obesity.
Research are
Metabolism
Alias
Small Heterodimer Partner, Orphan Nuclear Receptor SHP, Nuclear Receptor Subfamily 0 Group M member 2, NR0B2
Conjugate
Unconjugated
Specificity
Recognizes human SHP. Detects a band of ~30kDa by Western blot.
Immunogen
Recombinant human SHP.
Application notes
ELISA: (direct or indirect: 1:5, 000-1:10, 000). Western blot: (1:2, 000-1:10, 000 using ECL). Optimal conditions should be determined individually for each application.
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Storage
Stable for at least 1 year after receipt when stored at -20˚ C.
Concentration
1 mg/ml
Protein GI #
13259503
Accession #
NP_068804
NCBI Gene ID #
8431
NCBI symbol
NR0B2
NCBI full name
nuclear receptor subfamily 0, group B, member 2
NCBI organism
Homo sapiens
Swissprot #
Q15466

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Menge: 100 ug
Lieferbar: Out of stock
Listenpreis: 422,12 €
Preis: 422,12 €
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