IL-23 p40 Antibody [I 1108]

Hersteller ProSci
Kategorie
Typ Antibody Primary
Specific against Human
Clon I 1108
Isotype IgG1 kappa
Format Liquid
Applikationen WB, ELISA
Menge 100 ug
Host Mouse
ArtNr 36-033
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Background
IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11).
Research are
Cancer, Inflammation
Alias
Interleukin-23 Subunit p40, IL-23 Subunit p40, Interleukin-12 Subunit beta IL-12B, Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit, CLMF p40, IL-12 Subunit p40, NK Cell Stimulatory Factor Chain 2, NKSF2
Conjugate
Unconjugated
Specificity
Recognizes human IL-23p40. Does not cross-react with human IL-23p19.
Immunogen
Recombinant human IL-23p40.
Application notes
ELISA: (direct or indirect: 1:500-1:10, 000). Western blot: (1:500-1:5, 000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Storage
Stable for at least 1 year after receipt when stored at -20˚ C.
Concentration
1 mg/ml
Protein GI #
24497438
Accession #
NP_002178.2
NCBI Gene ID #
3593
NCBI symbol
IL12B
NCBI full name
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NCBI organism
Homo sapiens
Swissprot #
P29460

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Menge: 100 ug
Lieferbar: Out of stock
Listenpreis: 466,67 €
Preis: 466,67 €
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