ANGPTL4 Antibody [Kairos-1]

Hersteller ProSci
Kategorie
Typ Antibody Primary
Specific against Human
Clon Kairos-1
Isotype IgG1 kappa
Format Liquid
Applikationen WB, IHC, ELISA
Menge 100 ug
Host Mouse
ArtNr 36-040
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Immunogen
Recombinant human ANGPTL4.
Tested Applications
ELISA: (direct or indirect: 1:2, 000-1:5, 000). Immunohistochemistry: (paraffin sections (1:100-1:1, 000)). Western blot: (1:2, 000-1:5, 000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions should be determined individually for each application.
Specificity
Recognizes the fibrinogen-like domain (FLD) of human ANGPTL4. Detects a band of ca.62kDa and ca.35kDa by Western blot. Does not cross-react with other ANGPTL family proteins.
Conjugate
Unconjugated
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration
1 mg/ml
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
NCBI Official Symbol
ANGPTL4
Accession #
25008123
Protein GI #
Q9BY76
NCBI Gene ID
51129
User Note
Optimal dilutions for each application to be determined by the researcher.
NCBI Official Full Name
angiopoietin like 4
NCBI Organism
Homo sapiens
Swissprot
Q9BY76
Background
ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

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Menge: 100 ug
Lieferbar: In stock
Listenpreis: 434,85 €
Preis: 434,85 €
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