Nampt Antibody [OMNI379] (biotin)

Hersteller ProSci
Kategorie
Typ Antibody Primary
Specific against Human, Mouse, Rat
Clon OMNI379
Isotype IgG2a kappa
Format Liquid
Applikationen WB, IHC, ICC, ELISA
Menge 50 ug
Host Mouse
ArtNr 36-035
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Immunogen
Recombinant human Nampt (visfatin/PBEF).
Tested Applications
ELISA: (direct or indirect: 1:2, 000-1:10, 000). Immunocytochemistry: (1:500-1:1, 000). Immunohistochemistry: (paraffin sections, 1:100-1:500). Western blot: (1:2, 000-1:5, 000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.
Specificity
Recognizes human, mouse and rat Nampt.
Conjugate
Biotin
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration
1 mg/ml
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
NCBI Official Symbol
NAMPT
Accession #
5031977
Protein GI #
NP_005737
NCBI Gene ID
10135
User Note
Optimal dilutions for each application to be determined by the researcher.
NCBI Official Full Name
nicotinamide phosphoribosyltransferase
NCBI Organism
Homo sapiens
Swissprot
P43490
Background
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

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Menge: 50 ug
Lieferbar: In stock
Listenpreis: 466,67 €
Preis: 466,67 €
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