|
Hersteller |
ProSci
|
|
Kategorie |
|
|
Typ |
Antibody Polyclonal |
|
Specific against |
Human, Mouse, Rat |
|
Isotype |
IgG |
|
Format |
Liquid |
|
Applikationen |
WB, ELISA, IHC-P |
|
Menge |
0.02 mg |
|
Host |
Rabbit |
|
ArtNr |
4881-0.02 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Immunogen |
MettL7B antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human MettL7B.
The immunogen is located within the last 50 amino acids of MettL7B. |
| Tested Applications |
MettL7B antibody can be used for detection of Mettl7B by Western blot at 2 - 4 μ g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ g/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested. |
| Specificity |
This MettL7B antibody is predicted to not cross-react with MettL7A. |
| Positive Control 1 |
Cat. No. 1466 - Rat Spleen Tissue Lysate |
| Positive Control 2 |
Cat. No. 10-901 - Human Spleen Tissue Slide |
| Purification |
MettL7B Antibody is affinity chromatography purified via peptide column. |
| Conjugate |
Unconjugated |
| Buffer |
MettL7B Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration |
1 mg/mL |
| Storage Conditions |
MettL7B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| NCBI Official Symbol |
METTL7B |
| Accession # |
NP_689850 |
| Protein GI # |
164663805 |
| NCBI Gene ID |
196410 |
| User Note |
Optimal dilutions for each application to be determined by the researcher. |
| NCBI Official Full Name |
methyltransferase like 7B |
| NCBI Organism |
Homo sapiens |
| Swissprot |
Q6UX53 |
| Background |
MettL7B Antibody: MettL7B belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis. |
| Background References 1 |
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70. |
| Background References 2 |
Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26. |
| Background References 3 |
Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95. |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt und Sicherheitsdatenblatt) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
