Antibodies

MettL7B Antibody

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Hersteller ProSci
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Isotype IgG
Format Liquid
Applikationen WB, ELISA, IHC-P
Menge 0.02 mg
Host Rabbit
ArtNr 4881-0.02
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Immunogen
MettL7B antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human MettL7B.

The immunogen is located within the last 50 amino acids of MettL7B.
Tested Applications
MettL7B antibody can be used for detection of Mettl7B by Western blot at 2 - 4 μ g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity
This MettL7B antibody is predicted to not cross-react with MettL7A.
Positive Control 1
Cat. No. 1466 - Rat Spleen Tissue Lysate
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
Purification
MettL7B Antibody is affinity chromatography purified via peptide column.
Conjugate
Unconjugated
Buffer
MettL7B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration
1 mg/mL
Storage Conditions
MettL7B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
NCBI Official Symbol
METTL7B
Accession #
NP_689850
Protein GI #
164663805
NCBI Gene ID
196410
User Note
Optimal dilutions for each application to be determined by the researcher.
NCBI Official Full Name
methyltransferase like 7B
NCBI Organism
Homo sapiens
Swissprot
Q6UX53
Background
MettL7B Antibody: MettL7B belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.
Background References 1
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.
Background References 2
Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26.
Background References 3
Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95.

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Menge: 0.02 mg
Lieferbar: In stock
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