GITRL Antibody [MGTL 15]

Hersteller ProSci
Kategorie
Typ Antibody Primary
Specific against Mouse
Clon MGTL 15
Isotype IgG2a kappa
Format Liquid
Applikationen WB, ELISA
Menge 100 ug
Host Rat
ArtNr 36-009
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Background
GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis, . ). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Research are
Cancer, Immunology
Alias
Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18
Conjugate
Unconjugated
Specificity
Recognizes mouse GITRL. Detects a band of ~25kDa by Western blot. Does not cross-react with human GITRL.
Immunogen
Recombinant mouse GITRL.
Application notes
ELISA: (direct and indirect: 1:5, 000-1:10, 000). Flow Cytometry: (1:1, 000). Western blot: (1:2, 000-1:5, 000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.). Optimal conditions must be determined individually for each application.
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Storage
Stable for at least 1 year after receipt when stored at -20˚ C.
Concentration
1 mg/ml
Protein GI #
81894654
Accession #
Q7TS55
NCBI Gene ID #
240873
NCBI symbol
Tnfsf18
NCBI full name
tumor necrosis factor (ligand) superfamily, member 18
NCBI organism
Mus musculus
Swissprot #
Q7TS55

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Menge: 100 ug
Lieferbar: Out of stock
Listenpreis: 106,06 €
Preis: 106,06 €
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