Vergleich

MDA5 Antibody

Hersteller ProSci
Typ Antibody Primary
Specific against other
Isotype IgG
Applikationen E, WB, IF, IHC
Menge 1 mg
Host Rabbit
ArtNr 4037-1
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
BACKGROUND
MDA5 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-κ, B. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.
BY RESEARCH AREA
Innate Immunity
CONJUGATE
None
PURIFICATION
MDA5 Antibody is affinity chromatography purified via peptide column.
CLONALITY
This is a polyclonal MDA5 Antibody.
IMMUNOGEN
MDA5 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human MDA5.
TESTED APPLICATION
E, WB, IHC, IF
BUFFER
MDA5 Antibody is supplied in PBS containing 0.02% sodium azide.
USER NOTE
Optimal dilutions for each application to be determined by the researcher.
RELATED PRODUCTS
Cat. No. 4037P - MDA5 Peptide
STORAGE CONDITIONS
MDA5 antibody can be stored at 4C for three months and -20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
POSITIVE CONTROL 1
Cat. No. 1224 - Daudi Cell Lysate
POSITIVE CONTROL 2
Cat. No. 1369 - Human Lymph Node Tissue Lysate
SPECIES REACTIVITY
H, M
PROTEIN GI #
27886568
ACCESSION #
NP_071451
DISCLAIMER
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
PHYSICAL STATE
Liquid
CONCENTRATION
1 mg/mL
NCBI GENE ID #
64135
NCBI OFFICIAL SYMBOL
IFIH1
NCBI OFFICIAL FULL NAME
interferon induced with helicase C domain 1
NCBI ORGANISM
Homo sapiens

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt und Sicherheitsdatenblatt) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Menge: 1 mg
Lieferbar: In stock
lieferbar

Vergleichen

Auf den Wunschzettel

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?
 
Schließen