Recombinant Human IL-33 Protein

Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in highendothelial venules. It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities anda chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in humantonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs)and HeLa cells. The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling. IL-33mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitropolarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severepathological changes in mucosal organs. Human IL-33 is 270 amino acids in length.

No tag

Cytokines & Cytokine Receptors