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Biotinylated Mouse TNF-alpha Protein, His,Avitag™, active trimer (MALS verified)

Biotinylated Mouse TNF-alpha Protein, His,Avitag™, active trimer (MALS verified)

ArtNr	TNA-M82E9-200ug
Hersteller	ACROBiosystems
Menge	200 ug
Quantity options	200 ug 25 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293
Konjugat/Tag	Biotin, Avi
Purity	95%
Citations	(1) Dowlati Y, Herrmann N, et al., 2010, Biol Psychiatry 67 (5): 446-457. (2) Swardfager W, Lanctot K, et al., 2010, Biol Psychiatry 68 (10): 930-941. (3) Locksley RM, Killeen N et al., 2001, Cell 104 (4): 487-501.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFalpha
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-8xHis & C-Avi, Biotin-labeled
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	20.2 kDa
Manufacturer - Format	Powder
Description	Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Background	Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Molecule	TNF-alpha
Exp Region	Leu 80 - Leu 235
Characteristics	This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 20.2 kDa. The protein migrates as 20-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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TNA-M82E9-200ug-datasheet.pdf

TNA-M82E9-200ug-safety-datasheet.pdf