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Cynomolgus TSLP (R127A, R130S) Protein, His Tag (HPLC verified)

Cynomolgus TSLP (R127A, R130S) Protein, His Tag (HPLC verified)

ArtNr	TSP-C52H4-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 500 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Monkey (Cynomolgus, Simian)
Host	HEK293
Konjugat/Tag	Unconjugated
Purity	90%
Citations	(1) Segawa R., et al., 2017, J. Dermatol. Sci. S0923-1811:31012-31015. (2) Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106. (3) Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.
NCBI	XP_005557555.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TSLP
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Cynomolgus
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10xHis, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	16.9 kDa
Manufacturer - Format	Powder
Description	Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
Background	Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
Molecule	TSLP
Exp Region	Tyr 29 - Gln 159
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.9 kDa. The protein migrates as 21-30 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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TSP-C52H4-100ug-datasheet.pdf

TSP-C52H4-100ug-safety-datasheet.pdf