Antibodies

Rabbit anti-RBP4 (C-term.) [+Biotin]

Hersteller Raybiotech
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Format Supplied as lyophilized purified antibody. The antibody is stable for at least one year from the data of receipt when stored at -20C to -70C. Reconstituted antibody (suggesting with sterile PBS) can also be aliquotted and stored frozen at -20C to -70C in
Applikationen ELISA, EIA
Menge 50 ug
Host Rabbit
ArtNr RB-08-0032B-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Target Name
RBP4 (C-term.)
Accession Number
NM_006744
Conjugate/Tag/Label
Biotin
Application notes:
ELISA (recommended work dilution= 1:10, 000-20, 000 (at least detecting 2-5 ng/ml)), Western Blotting (recommended work dilution= 1:1000-5000(at least)), Enzyme Immunoassay (EIA)
Product Description
Retinol-binding protein 4 (RBP4) is a small transport protein (ca. 23 kDa) and belongs to the lipocalin family with diverse functions. It is the specific carrier protein for retinol (vitamin A alcohol) in the serum. It delivers retinol from the liver stores to the peripheral tissues. In human plasma, the RBPretinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. Recently, RBP4 was known to be one of adipokine secreted by adipocytes and relate to insulin resistance in the AG4KO mouse model. RBP4 may contribute to pathogenesis of type 2 diabetes. Yang et al. demonstrated that serum RBP4 levels are elevated in patients with obesity and type 2 diabetes.
Immunogen
Immunogen was synthetic peptide derived from human Retinol-binding protein 4. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation followed by Protein A/G affinity chromatography.

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Menge: 50 ug
Lieferbar: In stock
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