Recombinant Human BMP-13

Hersteller Raybiotech
Kategorie
Typ Proteins
Specific against Human
Menge 50 ug
ArtNr 229-20221
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Short Description
Purified recombinant BMP-13 expressed in E.coli
Introduction
Bone morphogenetic protein 13 (BMP-13), otherwise known as growth differentiation factor 6 (GDF6), is expressed in hypertrophic chondrocytes during embryonic development of long bones, and implicated as a regulator of the growth and maintenance of articular cartilage. BMP-13 is also expressed at the boundaries of developing carpals, tarsals, and vertebrae, and mutations in the BMP-13 gene, have been identified in both familial and sporadic cases of Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation. Functional BMP-13 is a disulfide-linked homodimer consisting of two 120 amino acid polypeptide chains, derived by proteolytic processing of a biologically inactive precursor protein.
Protein Name
BMP-13
Molecular Weight (kDa)
27.0kD (120 amino acid residue homodimer)
Purity
>95% by SDS PAGE and HPLC analysis
Formulation
0.1% Trifluoroacetic acid
Concentration
ca.0.1mg/ml after reconstitution
Preservative
None present
Endotoxin Level
<1EU/ug
Protein Type
Recombinant Protein
Recommended Applications
Functional Assays
Biological activity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µ g/ml.
Reconstitution
Reconstitute with 500ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. RayBiotech recommends that the vial is gently mixed after reconstitution.
Storage/stability
Prior to reconstitution store at +4° C.
After reconstitution store at -20° C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. This protein may be stored for3 months from date of reconstitution.
Menge: 50 ug
Lieferbar: Out of stock
Listenpreis: 559,08 €
Preis: 559,08 €
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