Recombinant Human PERSEPHIN

Hersteller Raybiotech
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
ArtNr 229-20230
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Short Description
Purified recombinant PSPN expressed in E.coli
Introduction
Persephin (PSPN) is a neurotrophic protein and member of the Glial cell line-derived neurotrophic factor (GDNF) family, which plays a key role in the development of the central nervous system (CNS). PSPN is synthesized throughout the nervous system, and promotes ventral midbrain dompaminergic neuron survival and ureteric bud branching, but unlike GDNF and Neurturin, does not support peripheral neuron survival. PSPN signals through a multicomponent complex consisting of the binding receptor GFRalpha4, co-expressed with the signalling Ret receptor tyrosine kinase.
Protein Name
PERSEPHIN
Molecular Weight (kDa)
10.3kD (192 amino acid homodimer)
Purity
>98% by SDS PAGE and HPLC analysis
Concentration
ca.0.1mg/ml after reconstitution
Preservative
None present
Endotoxin Level
<1EU/ug
Protein Type
Recombinant Protein
Recommended Applications
ELISA (0.2-0.4ng/well), Functional Assays, Western Blotting (1.5-3.0ng/lane)
Biological activity
Induces RET phosphorylation using a concentration range of 0.1-1.0 ng/ml. Binds to mammalian GFRalpha4 with the Kd of 100pM.
Reconstitution
Reconstitute with 0.2ml distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. RayBiotech recommends that the vial is gently mixed after reconstitution.
Storage/stability
Prior to reconstitution store at +4° C.
After reconstitution store at -20° C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. This protein may be stored for3 months from date of reconstitution.
Menge: 20 ug
Lieferbar: Out of stock
Listenpreis: 559,08 €
Preis: 559,08 €
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