Antibodies

Anti-VEGFA Antibody

Hersteller St John's Laboratory
Kategorie
Typ Antibody
Specific against Human, Mouse, Rat
Applikationen WB, IF
Menge 50ul
Host Rabbit
ArtNr STJ114190-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Description
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
Short Description
Rabbit polyclonal to VEGFA
Alternative names
VEGFA antibody
Vascular endothelial growth factor A antibody
VEGF-A antibody
Vascular permeability factor antibody
VPF antibody
VEGFA antibody
VEGF antibody
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution range
WB 1:500 - 1:2000
IF 1:50 - 1:200
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene id
Gene symbol
Immunogen
Recombinant protein of human VEGFA
Iso type
IgG
Molecular weight
27.042 kDa
Note
For Research Use Only (RUO).
Purification
Affinity purification
Storage instruction
Store at -20C. Avoid freeze / thaw cycles.
Swiss prot key
Tissue specificity
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed, Isoform VEGF206 and isoform VEGF145 are not widely expressed, A higher level expression seen in pituitary tumors as compared to the pituitary gland
Uniprot id
P15692

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Menge: 50ul
Lieferbar: In stock
Listenpreis: 235,71 €
Preis: 235,71 €
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