Anti-VEGFA antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P15692

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

VEGFA

Rabbit polyclonal against VEGFA

Secreted
Vegf121 Is Acidic And Freely Secreted
Vegf165 Is More Basic
Has Heparin-Binding Properties And
Although A Significant Proportion Remains Cell-Associated
Most Is Freely Secreted
Vegf189 Is Very Basic
It Is Cell-Associated After Secretion And Is Bound Avidly By Heparin And The Extracellular Matrix
Although It May Be Released As A Soluble Form By Heparin
Heparinase Or Plasmin

WB 1:500-1:2000 IF 1:50-1:200

Vascular Endothelial Growth Factor A
Vegf-A
Vascular Permeability Factor
Vpf

VEGFA_HUMAN