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Anti-PPARGC1A antibody

Anti-PPARGC1A antibody

Hersteller	St John's Laboratory
Kategorie	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies By Cell Type Carcinoma Western Blot Primary Antibodies By Organ Thyroid Cancer Other Lipid\Cholesterol Metabolism Modulators
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Isotype	IgG
Applikationen	WB
Menge	50ul
Host	Rabbit
ArtNr	STJ114227-50
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	Q9UBK2
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Gene ID	10891
Gene symbol	PPARGC1A
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human PPARGC1A (NP_037393. 1).
Short Description	Rabbit polyclonal against PPARGC1A
Tissue specificity	Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
Cellular localization	Isoform 1: Nucleus Nucleus Pml Body Isoform B4: Nucleus Isoform B4-8a: Cytoplasm Isoform B5: Nucleus Isoform 9: Nucleus
Molecular weight	Calculated: 14kDa/30kDa/31kDa/33kDa/77kDa/89kDa/91kDa. Observed: 115kDa/120kDa
Dilution range	WB 1:500-1:2000
Alternative names	Anti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha antibody Anti-Pgc-1-Alpha antibody Anti-Ppar-Gamma Coactivator 1-Alpha antibody Anti-Ppargc-1-Alpha antibody Anti-Ligand Effect Modulator 6 antibody Anti-PPARGC1A LEM6 PGC1 PGC1A PPARGC1 antibody
Protein name	Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha Pgc-1-Alpha Ppar-Gamma Coactivator 1-Alpha Ppargc-1-Alpha Ligand Effect Modulator 6
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	PRGC1_HUMAN

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Menge: 50ul

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