3-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine

Hersteller Toronto Research Chemicals
Kategorie
Typ Biochemicals
Specific against other
Menge 0,25mg
ArtNr TRC-K171000-0,25mg
eClass 6.1 32160405
eClass 9.0 32160490
Lieferbar
Synonym
KAAD-Cyclopamine; 11-Deoxyjervine
CAS Number
306387-90-6
Mol. Formula
C44H63N3O4
Mol. Weight
697, 99
Melting Pt.
105-111C
Application Notes
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ß-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.

KAAD-Cyclopamine compound is unstable in solution.
References
Taipale, J., et al.: Nature, 406, 1005 (2000); Perron, M., et al.: Development, 130, 1565 (2003);
Menge: 0,25mg
Lieferbar: Out of stock
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