Antibodies

Phospho-ABL1-Y412

Manufacturer Abclonal
Category Products / Antibody
Type Antibody Polyclonal
Specific against Human, Mouse
Isotype IgG
Applications IF, IHC
Amount 200ug
Host Rabbit
ArtNr AP0303-200ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Available
Background
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9; 22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
Gene Symbol
ABL1
Gene Template
Human
GeneID
25
Route
Synthetic Peptide
SWISS
P00519
Protein MW (aa)
122kDa
Synonyms
ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl,
Purity
Affinity purification
Storage Buffer
Store at -20C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions
IHC 1:50 - 1:100
IF 1:100 - 1:200
Illustration
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-ABL1-Y412 antibody. Immunofluorescence staining of methanol-fixed HeLa cells using Phospho-ABL1-Y412 antibody.
Amount: 200ug
Available: In stock
Listprice: €491.00
Price: €491.00
lieferbar

Get an offer

Technische Fragen zu diesem Produkt?


Salesmanager: Arne Pelz

Email: sales@hoelzel.de

Instruction sheet

AP0303-200ug.pdf